John Wayne Casserole

What could be more mid-Western and cowboy themed than a casserole named after John Wayne? This meal doesn't have to only be eaten out on the range, though; packed with dairy and beef, this is a filling and satisfying casserole for any occasion!

A slice of layered casserole with ground beef, tomatoes, and a cheesy, creamy topping is served on a white plate with a fork. The casserole appears hearty and baked, with a golden brown top.
5 from 2 vote(s)7 comments
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Why You’ll Love My Recipe

Meat and cheese with a whole lot of delicious flavours thrown in. Need I say more? This filling and easy-to-make casserole is perfect for when you need a hearty meal in under an hour!

Why not try making your own Taco Seasoning for this recipe? Maybe even your own Homemade Bisquick Mix as well? Change up the meat and cheese a little to really make this meal your own.

A casserole dish filled with a baked cheesy potato casserole, topped with melted golden cheese. A wooden spoon rests nearby on a white marble surface, with a sprig of fresh parsley in the corner.

Karlynn’s Recipe Notes

  • Skill Level: Like most casseroles, this one is nice and easy to make.
  • Total Time: You can have this casserole done in under an hour.
  • Variations: There are a multitude of ways that you can personalize this casserole. Try adding corn, or some chopped red pepper. Why not add an Avocado, Black Bean & Corn Salad on the side to go along with the Western theme of this dish.
  • Tools You’ll Need: A large frying pan, a small frying pan, a 9″x13″ casserole dish, a couple of bowls, and some basic cooking utensils.
A wooden spoon lifts a serving of cheesy casserole with ground beef, vegetables, and a golden, crispy topping from a white baking dish in a kitchen setting.

What You’ll Need For Ingredients

Biscuit Mix: You can use my Homemade Bisquick Mix Recipe, your own biscuit mix, or a mix from the store. Whatever works for you.

Taco Seasoning: Try my recipe for Cheap and Easy Homemade Taco Seasoning.

Ground Meat: I used ground beef for this recipe, but you could use any ground meat. Try ground chicken or ground turkey for leaner options, or ground pork for a different flavour.

Cheese: Cheddar or any other shredded cheese you enjoy. Something with some heat to it, something aged and sharp, maybe something extra melty.

Various ingredients for a recipe are arranged on a white marble surface, including ground meat, chopped onions, green peppers, seasonings, shredded cheese, sour cream, diced tomatoes, flour, and glass jars of water.

How To Make John Wayne Casserole

This is a brief overview of the recipe. The full list of ingredients and step-by-step instructions are in the recipe card below.

  1. Preheat your oven to 325°F. Grease and set aside a 9″x13″ casserole dish.
  2. Cook and drain your ground meat.
  3. Add taco seasoning and water. Let simmer for 3-4 minutes.
  4. In a medium bowl, mix sour cream, mayonnaise, half of the cheese and half of the onion. Set that aside.
  5. In a separate bowl, mix the biscuit mix with water. Press the mixed dough into the bottom of the 9″x13″ pan, making sure it comes halfway up the sides of the dish.
  6. Cook the green pepper and the other half of the onion in a small pan until tender.
  7. Layer the rest of the ingredients, following this order: ground beef, diced tomatoes, cooked green pepper and onion, green chilies, sour cream mixture, and then the remaining cheese.
  8. Bake for 30-35 minutes.
A close-up of a slice of casserole with layers of seasoned ground beef, tomatoes, onions, green chiles, and melted cheddar cheese on top, served on a white plate with a fork.

Karlynn’s Tips and Tricks for Making Perfect John Wayne Casserole

  • Extra Cheese: Try adding extra cheese on top of this casserole! A Monterey Jack or something with hot peppers, maybe. Or a smoked cheese to add a lovely smoky flavour.
  • Grease Your Pan: Remember to grease your pan before assembling this casserole, unless, of course, you enjoy scraping cooked cheese off of ceramic or glass.
  • Food Prep: Do all of your chopping and grating in advance so that when it’s time to layer your ingredients, you won’t have to scramble to get it all done.
A white baking dish filled with a baked casserole topped with melted cheddar cheese, with one serving missing. The dish sits on a marble surface near plates, a glass of water, and a white towel with blue stripes.

Storage Instructions

Fridge: Cover in plastic wrap or a lid and keep in your fridge for a day or so, but it’s got plenty of vegetables and dairy so it might get a bit watery and mushy if you leave it for any longer.

Freezer: As soon as your casserole has cooled down enough that you can handle the pan and it won’t melt everything in your freezer, cover it with plastic wrap. Freeze it in its original dish. Take off the plastic and reheat your casserole at 200°F for at least an hour, rotating it occasionally. Broil for the last 5 minutes if you’d like the cheese to crisp up.

More Delicious Casserole Recipes

Looking for more delicious Casserole recipes?

If you’re a big fan of chicken, check out Chicken Bacon Ranch Casserole, Classic Chicken Divan, or Quick Chicken and Noodles.

Broccoli Rice Casserole would make a great side for any protein.

Why not try a sweet Banana Cinnamon Roll Casserole for breakfast or dessert?

There you go, friends. An easy, satisfying casserole that is as big and bold as its namesake. Try it out and let me know what you think.

Happy Cooking!

Karlynn

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John Wayne Casserole

What could be more mid-Western and cowboy themed than a casserole named after John Wayne? This meal doesn't have to only be eaten out on the range, though; packed with dairy and beef, this is a filling and satisfying casserole for any occasion!
5 from 2 votes
Prep: 10 minutes
Cook: 35 minutes
Servings: 8
Calories: 544

Ingredients 

  • 2 pounds ground beef
  • 2 tablespoons taco seasoning
  • ¾ cup water
  • ½ cup sour cream
  • ½ cup mayonnaise
  • 1 cup shredded cheddar cheese divided
  • 1 onion finely chopped and divided
  • 2 cups Homemade Bisquick Mix
  • 1 cup water
  • 1 green pepper diced
  • 2 tomatoes diced
  • 4 ounces diced green chilies

Instructions 

  • Preheat your oven to 325 degrees Fahrenheit.
  • Take out a 9×13 casserole dish and set aside. Grease it lightly with cooking spray.
  • Brown ground beef until no longer pink and drain.
  • Add in my homemade taco seasoning, mixed with some warm water and let simmer for 3-4 minutes (to thicken)
  • In a medium sized bowl mix in the sour cream, mayonnaise, one half of the cheese, and half of the finely chopped onion. Set aside.
  • In a new bowl, mix together my homemade biscuit mix and water until it forms a dough.
  • Press this newly formed dough into the greased 9 x 13 inch pan, making sure it goes at least half way up the sides of the dish.
  • Cook together the remaining onions and green peppers until tender.
  • Layer the remaining ingredients into the 9×13 on top of the dough in the following order: ground beef, diced tomatoes, green peppers and onions, green chilies, sour cream mixture, and remaining cheddar cheese.
  • Bake for 30-35 minutes or until edges are slightly browned.

Nutrition

Calories: 544kcal | Carbohydrates: 23g | Protein: 26g | Fat: 38g | Saturated Fat: 15g | Polyunsaturated Fat: 3g | Monounsaturated Fat: 15g | Trans Fat: 1g | Cholesterol: 106mg | Sodium: 718mg | Potassium: 441mg | Fiber: 1g | Sugar: 6g | Vitamin A: 318IU | Vitamin C: 3mg | Calcium: 202mg | Iron: 3mg

Nutrition information is automatically calculated, so should only be used as an approximation.

Like this? Leave a comment below!

Karlynn Johnston

I’m a busy mom of two, wife & cookbook author who loves creating fast, fresh meals for my little family on the Canadian prairies. Karlynn Facts: I'm allergic to broccoli. I've never met a cocktail that I didn't like. I would rather burn down my house than clean it. Most of all, I love helping YOU get dinner ready because there's nothing more important than connecting with our loved ones around the dinner table!

Learn more about me

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Reader Interactions

Comments & Recipe Tips Share a tip or comment!

  1. Fran Laroche says

    Very good…..Tip, don’t use the full cup of water to the Bisquick because it is too wet so start with 1/2 cup then add a bit at a time. I had to add more Bisquick.5 stars

  2. Michelle Gibson says

    Looks very good and easy to make. I also saved your tomato and beef recipe.

  3. C.B. says

    Also under “How to Store and Reheat this Casserole,” you say: “When you want to reheat it, take the whole thing out of the oven and put it in the fridge on low, about 200 Fahrenheit, for at least an hour, turning it occasionally.” I think you meant to say take the whole thing out of the fridge and put it in the oven on low” yes?

  4. CB. says

    Under “How to Make” instead of “stir into warm hotter” did you mean warm water?

5 from 2 votes

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